Serum levels of P-selectin in men with high-functioning autism.
نویسندگان
چکیده
Immune dysfunction has been proposed as a mechanism for the pathophysiology of autistic-spectrum disorders. The selectin family of adhesion molecules plays a prominent role in immune/inflammatory responses. We determined the serum levels of three types of soluble-form selectin (sP, sL and sE) in 15 men with high-functioning autism and 22 age-matched healthy controls by enzyme-linked immunosorbent assay. Levels of sP-selectin and sL-selectin were significantly lower in patients than in controls. Furthermore, sP-selectin levels were negatively correlated with impaired social development during early childhood.
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عنوان ژورنال:
- The British journal of psychiatry : the journal of mental science
دوره 193 4 شماره
صفحات -
تاریخ انتشار 2008